Faculty of Art and Science

Academic Members

Nazlıhan  Aztopal

Nazlıhan Aztopal,  Dr.

CV
Faculty Member

Nazlıhan Aztopal has completed Bachelor’s degree in Department of Biology, Faculty of Science, Uludag University with the best second student degree in 2010. She had M.Sc. degree in 2013 and Ph.D. degree in 2017 with the thesis entitled as “Investigating the dynamics between histone modifications and cell death in breast cancer stem cells” in Institute of Science, Molecular Biology Department at the same university. During her Ph.D. education, she has involved in “Cancer Stem Cell” studies in the National Institute of Cancer Research (Fondazione IRCCS Istituto Nazionale dei Tumori, Italy) as a guest researcher. Since 2017, she has been assigned as an assistant professor in Istinye University.

Research Area: Cancer Biology, Cancer stem cell, Cell Death, Anticancer drug development, Epigenetics

Main Areas: Moleküler Biyoloji ve Genetik,  Moleküler Biyoloji, 

2020 - Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines
Balikci Necmiye,SARIMAHMUT MEHMET,ARI FERDA,AZTOPAL NAZLIHAN,Özel MustafaZafer,ULUKAYA ENGİN,ÇELİKLER KASIMOĞULLARI SERAP. Journal of Applied Biomedicine, 18(1), 18-25.
2020 - A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
Erkisa M.,aydinlik seyma,Cevatemre Buse,AZTOPAL NAZLIHAN,AKAR REMZİ OKAN,ÇELİKLER KASIMOĞULLARI SERAP,YILMAZ VEYSEL TURAN,ARI FERDA,ULUKAYA ENGİN. Biochimie, 175(), 159-172.
2019 - Key actors in cancer therapy: epigenetic modifiers
AKAR REMZİ OKAN,Selvi Selin,ULUKAYA ENGİN,AZTOPAL NAZLIHAN. TURKISH JOURNAL OF BIOLOGY, 43(3), 155-170.
2019 - Paclitaxel resistance and the role of miRNAs in prostate cancer cell lines
ŞAMLI HALE,ŞAMLI M.MURAT,VATANSEVER BUSE,ARDIÇLI SENA,AZTOPAL NAZLIHAN,DİNÇEL DENİZ,ŞAHİN AHMET,BALCI FARUK. World Journal of Urology, 37(6), 1117-1126.
2018 - A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
CEVATEMRE BUSE,ERKISA MERVE,AZTOPAL NAZLIHAN,KARAKAŞ DİDEM,Alper Pinar,Tsimplouli Chrisiida,Sereti Evangelia,Dimas Konstantinos,ARMUTAK ELİF İLKAY,GÜREL GÜREVİN EBRU,ÜVEZ AYÇA,Mori Mattia,Berardozzi Simone,Ingallina Cinzia,D’xxAcquarica Ilaria,Botta Bruno,Ozpolat Bulent,ULUKAYA ENGİN. PHARMACOLOGICAL RESEARCH, 129(null), 500-514.
2018 - Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
AZTOPAL NAZLIHAN,Erkisa Merve,ERTÜRK ELİF,ULUKAYA ENGİN,TOKULLUGİL HATİCE ASUMAN,ARI FERDA. CHEMICO-BIOLOGICAL INTERACTIONS, 280(), 51-58.
2017 - A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
AZTOPAL NAZLIHAN,KARAKAŞ DİDEM,CEVATEMRE BUSE,ARI FERDA,İÇSEL CEYDA,Daidone Maria,ULUKAYA ENGİN. Bioorganic & Medicinal Chemistry, 25(1), 269-276.
2017 - Effect of Aspartame on Acetylcolinesterase Activity in Different Rat Tissues.
POLAT FİKRİYE,DERE EGEMEN,ARI FERDA,TURAÇLAR NESRİN,BİNGÖL GÜNSEL,AZTOPAL NAZLIHAN. Hacettepe Journal of Biology and Chemistry, 45(3), 321-327.
2017 - Nonapoptotic cell death induced by Hypericum species oncancer cells
ARI FERDA,AZTOPAL NAZLIHAN,erkısa merve,ÇELİKLER KASIMOĞULLARI SERAP,ŞAHİN SALİHA,ULUKAYA ENGİN. The European Research Journal, 3(1), 1-10.
2017 - Effect of Aspartame on Acetylcholinesterase Activity in Some of Rat Tissues
POLAT FİKRİYE,DERE EGEMEN,ARI FERDA,TURAÇLAR NESRİN,BİNGÖL GÜNSEL,AZTOPAL NAZLIHAN. Hacettepe Journal of Biology and Chemistry, 3(45), 321-327.
2016 - Ni(II)/Cu(II)/Zn(II) 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2 ’xx-dipyridylamine: synthesis, structures, DNA/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death
YILMAZ VEYSEL TURAN,İÇSEL CEYDA,suyunova Feruza,AYGÜN MUHİTTİN,AZTOPAL NAZLIHAN,ULUKAYA ENGİN. DALTON TRANSACTIONS, 45(25), 10466-10479.
2016 - Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L. and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro: Involvement of DNA Damage
AZTOPAL NAZLIHAN,Erkısa Merve,ÇELİKLER KASIMOĞULLARI SERAP,ULUKAYA ENGİN,ARI FERDA. JOURNAL OF FOOD BIOCHEMISTRY, 40(4), 559-566.
2016 - Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines
AZTOPAL NAZLIHAN,Cevatemre Buse,SARIMAHMUT MEHMET,ARI FERDA,DERE EGEMEN,Özel Mustafa Zafer,FIRAT MEHMET,ULUKAYA ENGİN. ONCOLOGY LETTERS, 12(2), 1429-1437.
2015 - Addition of niclosamide to palladium(II) saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer
KARAKAŞ DİDEM,cevatemre buse,AZTOPAL NAZLIHAN,ARI FERDA,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN. BIOORGANIC MEDICINAL CHEMISTRY, 23(17), 5580-5586.
2014 - Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo
ARI FERDA,Cevatemre Buse,ARMUTAK ELİF İLKAY,AZTOPAL NAZLIHAN,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN. BIOORGANIC MEDICINAL CHEMISTRY, 22(17), 4948-4954.
2014 - Genotoxic, cytotoxic, and apoptotic effects of crude extract of Usnea filipendula Stirt. in vitro
ÇELİKLER KASIMOĞULLARI SERAP,ORAN SEYHAN,ARI FERDA,ULUKAYA ENGİN,AZTOPAL NAZLIHAN,SARIMAHMUT MEHMET,ÖZTÜRK ŞULE. TURKISH JOURNAL OF BIOLOGY, 38(6), 940-947.
2014 - Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells
ARI FERDA,AZTOPAL NAZLIHAN,ORAN SEYHAN,Bozdemir Sezin,ÇELİKLER KASIMOĞULLARI SERAP,ÖZTÜRK ŞULE,ULUKAYA ENGİN. CELL PROLIFERATION, 47(5), 457-464.
2013 - Synthesis, structural characterization and cell death-inducing effect of novel palladium(II) and platinum(II) saccharinate complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl) pyridine on cancer cells in vitro
ARI FERDA,AZTOPAL NAZLIHAN,İÇSEL CEYDA,YILMAZ VEYSEL TURAN,güney emel,BÜYÜKGÜNGÖR ORHAN,ULUKAYA ENGİN. BIOORGANIC MEDICINAL CHEMISTRY, 21(21), 6427-6434.
Moleküler Kanser Biyolojisi
2018 - Türkçe, Bilimsel Kitap
ISBN: 9786052329306
Cevatemre Buse,AZTOPAL NAZLIHAN,ULUKAYA ENGİN