Faculty of Art and Science

Academic Members

Didem  Karakaş Zeybek

Didem Karakaş Zeybek,  Dr.

CV
Faculty Member

Didem Karakaş has completed Bachelor’s degree in Uludag University Faculty of Science and Literature Biology Department in 2011. She had MSc degree in 2013 and PhD degree in 2017 in Institute of Science, Molecular Biology Department at the same university. She completed her PhD thesis project on “Targeting pancreatic cancer and tumor microenvironment through eukaryotic elongation factor 2 kinase (EF2K) inhibition” in M.D. Anderson Cancer Center in U.S.A, with the support of TUBITAK 2214-A Scholarship Program. Since 2017, she has been assigned as an assistant professor in Istinye University. She has conducted 2 national research projects funded by TUBITAK (TUBITAK 1001 and TUBITAK 3501).

Main Areas: Moleküler Biyoloji ve Genetik,  Moleküler Biyoloji, 

2020 - Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target
KARAKAŞ DİDEM,ozpolat bulent. Journal of Molecular Medicine, 98(6), 775-787.
2019 - Cancer Stem Cells: Root of the Evil
ERKISA MERVE,KARAKAŞ DİDEM,ULUKAYA ENGİN. Critical Reviews™ in Oncogenesis, 24(1), 69-87.
2019 - Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
KARAKAŞ DİDEM,CEVATEMRE BUSE,YILMAZTEPE ORAL ARZU,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN. Anti-Cancer Agents in Medicinal Chemistry, 19(9), 1184-1195.
2019 - A Novel 1,4-Naphtoquinone-Derived Compound Induces Mitochondria-Mediated Apoptotic Cell Death in Breast Cancer Cells
KARAKAŞ DİDEM,AKAR REMZİ OKAN,GÖKMEN ZELİHA,DENİZ NAHİDE GÜLŞAH,ULUKAYA ENGİN. TURKISH JOURNAL OF BIOLOGY, 43(), 256-263.
2019 - Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
GÖKMEN ZELİHA,ONAN MEHMET ERDİ,DENİZ NAHİDE GÜLŞAH,KARAKAŞ DİDEM,ULUKAYA ENGİN. SYNTHETIC COMMUNICATIONS, 49(21), 3008-3016.
2018 - Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
BAYRAKTAR RECEP,ivan cristina,Bayraktar Emine,KANLIKİLİÇER PINAR,KABIL NASHWA N,Kahraman Nermin,MOKHLIS HAMADA A,KARAKAŞ DİDEM,RODRIGUEZ AGUAYO CRİSTİAN,ARSLAN AHMET,SHENG JİANTİNG,WONG STEPHEN,Lopez-Berestein Gabriel,Calin George,Ozpolat Bulent. Clinical Cancer Research, 24(17), 4225-4241.
2018 - A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
CEVATEMRE BUSE,ERKISA MERVE,AZTOPAL NAZLIHAN,KARAKAŞ DİDEM,Alper Pinar,Tsimplouli Chrisiida,Sereti Evangelia,Dimas Konstantinos,ARMUTAK ELİF İLKAY,GÜREL GÜREVİN EBRU,ÜVEZ AYÇA,Mori Mattia,Berardozzi Simone,Ingallina Cinzia,D’xxAcquarica Ilaria,Botta Bruno,Ozpolat Bulent,ULUKAYA ENGİN. PHARMACOLOGICAL RESEARCH, 129(null), 500-514.
2017 - A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
AZTOPAL NAZLIHAN,KARAKAŞ DİDEM,CEVATEMRE BUSE,ARI FERDA,İÇSEL CEYDA,Daidone Maria,ULUKAYA ENGİN. Bioorganic & Medicinal Chemistry, 25(1), 269-276.
2017 - Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
TUNÇ DUYGU,DERE EGEMEN,KARAKAŞ DİDEM,CEVATEMRE BUSE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN. Bioorganic Medicinal Chemistry, 25(5), 1717-1723.
2017 - Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
Tunç Duygu,DERE EGEMEN,KARAKAŞ DİDEM,CEVATEMRE BUSE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN. BIOORGANIC MEDICINAL CHEMISTRY,
2017 - Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells
ARI FERDA,ÇELİKLER KASIMOĞULLARI SERAP,KARAKAŞ DİDEM,CEVATEMRE BUSE,FIRAT MEHMET,ULUKAYA ENGİN. Journal of Clinical and Experimental Investigations, 8(1), 22-30.
2017 - Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells
ARI FERDA,ÇELİKLER KASIMOĞULLARI SERAP,KARAKAŞ DİDEM. journal of clinical and experimental investigations,
2017 - The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
KARAKAŞ DİDEM,ARI FERDA,ULUKAYA ENGİN. TURKISH JOURNAL OF BIOLOGY, 41(), 919-925.
İleri Mitokondriyal Tıp
2020 - Türkçe, Kitap Tercümesi
ISBN: 978-605-69722-1-8
AKÇAY YASEMİN,KELEŞ BARTIK DİDEM,OKTAY GÜLGÜN,İNANÇ ŞENİZ,SİPAHİ MURAT,ABBAN TOLGA,AKKURT SİNAN,KAPLAN ALGIN ASUMAN,KURT DEMİRTAŞ YAĞMUR,DEMİR KESEN ŞEYMA,DENİZOĞLU BURCU,DURMAZ BURAK,ERGÜN PELİN,ÖZBEK İPTEÇ BETÜL,KARADADAŞ ELİF,KOCAMANOĞLU MELTEM,BARAN ALPER,YILDIRIR ÇİĞDEM GÖZDE,ARAL CENK,CANBAY ERHAN,ERCAN GÜLİNNAZ,HANCI İSMAİL HAMİT,İLHAN NECİP,İLHAN NEVİN,KARAKAŞ DİDEM,KOZACI LEYLA DİDEM,GİRGİN SAĞIN FERHAN,SEZER EBRU,YILDIRIM SÖZMEN ESER,SUSAM SOLMAZ,ULUKAYA ENGİN,UYGUN ZİHNİ ONUR