Faculty of Art and Science

Academic Members

Sinem Fırtına

Sinem Fırtına,  Dr.

CV
Faculty Member

Sinem Fırtına graduated from Marmara University Biology department. She obtained master degree in Immunology and PhD degree in Medical Genetics from Istanbul University Aziz Sancar Institute for Experimental Research. She was a researcher in the project of the inter-laboratory robustness of next-generation sequencing (IRON) II study with the European Leukemia Network (ELN) group and have been found in Italy for learning next generation sequencing (NGS) techniques. She sequenced more than 100 pediatric leukemia patients and identify cancer clones, novel driver and passenger mutations and screened 200 primary immunodeficiency patients for detecting disease-related mutations.

Research Area: Identifying clonal changes in pediatric leukemia, Detecting disease-related mutations in primary immunodeficiencies, Next generation sequencing techniques, Epigenetic rearrangements

Main Areas: TIP, 

2020 - Mutational landscape of severe combined immunodeficiency patients from Turkey
FIRTINA SİNEM,Yin Ng Yuk,Hatirnaz Ng Ozden,KIYKIM AYÇA,AYDINER ELİF,NEPESOV SERDAR,Camcioglu Yildiz,Sayar Esra H,REİSLİ İSMAİL,Torun Selda H,Cogurlu Tuba,KOCACIK UYGUN DİLARA FATMA,ESER ŞİMŞEK IŞIL,Kaya Aysenur,ÇİPE FUNDA,ÇAĞDAŞ AYVAZ DENİZ NAZİRE,YÜCEL ESRA,ÇEKİÇ ŞÜKRÜ,UYGUN VEDAT,BARIŞ SAFA,ÖZEN AHMET OĞUZHAN,Ozbek Ugur,Sayitoglu Muge. International Journal of Immunogenetics, 47(6), 529-538.
2020 - Clinical and immunological features of 44 common variable immunodeficiency patients: The experience of a single center in Turkey
nepesov serdar,Aygun Fatma Deniz,FIRTINA SİNEM,ÇOKUĞRAŞ HALUK CEZMİ,CAMCIOĞLU YILDIZ. Allergologia et Immunopathologia,
2020 - Lymphoma Predisposing Gene in an Extended Family: CD70 Signaling Defect
Khodzhaev Khusan,Bay Sema Buyukkapu,KEBUDİ REJİN,Altindirek Didem,KAYA AYŞENUR,ERBİLGİN YÜCEL,HATIRNAZ NG Özden,KIYKIM AYÇA,ÇİPE FUNDA,Zengin feride sen,FIRTINA SİNEM,NG YUK YIN,Aksoy Basak Adakli,SAYİTOĞLU MÜGE. JOURNAL OF CLINICAL IMMUNOLOGY,
2020 - PTEN and AKT1 Variations in Childhood T-cell Acute Lymphoblastic Leukemia
KÜÇÜKCANKURT FULYA,ERBİLGİN YÜCEL,FIRTINA SİNEM,HATIRNAZ NG ÖZDEN,KARAKAŞ ZEYNEP,CELKAN TİRAJE,ÜNÜVAR AYŞEGÜL,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. Turkish Journal of Hematology, 37(2), 98-103.
2020 - Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency
FIRTINA SİNEM,ERMAN BARAN,FIŞGIN TUNÇ,BOZKURT CEYHUN,ÇİPE FUNDA. Journal of Clinical Immunology, 40(3), 539-542.
2019 - Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia.
FIRTINA SİNEM,ERBİLGİN YÜCEL,ng OH,CELKAN TÜLİN TIRAJE,KARAKAŞ ZEYNEP,aydoğan gönül,türkkan emine,SAYİTOĞLU MÜGE. Blood and Cancer,
2019 - Prognostic gene alterations and clonal changes in childhood B-ALL
ERBİLGİN YÜCEL,FIRTINA SİNEM,MERCAN SEVCAN,HATIRNAZ NG Özden,KARAMAN SERAP,TAŞAR ORÇUN,KARAKAŞ ZEYNEP,CELKAN TÜLİN TIRAJE,ZENGİN EMİNE,SARPER NAZAN,YILDIRMAK ZEYNEP YILDIZ,şişko sinem,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. leukima research,
2019 - A Novel FOXN1 Variant Is Identified in Two Siblings with Nude Severe Combined Immunodeficiency
FIRTINA SİNEM,ÇİPE FUNDA,NG YUK YIN,KIYKIM AYÇA,HATIRNAZ NG Özden,SUDUTAN TUĞÇE,AYDOĞMUŞ ÇİĞDEM,BARIŞ SAFA,ÖZTÜRK HANİFE GÜLYÜZ,AYDINER ELİF,ÖZEN AHMET OĞUZHAN,SAYİTOĞLU MÜGE. J Clin Immunol, 144-147.
2018 - 8q24 bölgesi çocukluk çağı lenfoblastik lösemiler için potansiyel risk oluşturur mu?
HATIRNAZ NG Özden,can ismail,FIRTINA SİNEM,ERBİLGİN Yücel,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. Deneysel Tıp Dergisi,
2018 - Deep sequencing of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia patients with resistance to tyrosine kinase inhibitors
ERBİLGİN Yücel,Eskazan Ahmet Emre,HATIRNAZ NG Özden,Salihoglu Ayse,Elverdi Tugrul,FIRTINA SİNEM,Tasar Orcun,MERCAN SEVCAN,Sisko Sinem,Khodzhaev Khusan,Ongoren Seniz,AR MUHLİS CEM,Baslar Zafer,SOYSAL TEOMAN,SAYİTOĞLU MÜGE,ÖZBEK UĞUR. Leukemia Lymphoma, 1-9.
2018 - Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1–5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues
Ozkaya Hande Mefkure,Comunoglu Nil,SAYİTOĞLU MÜGE,KESKİN FATMA ELA,FIRTINA SİNEM,Khodzhaev Khusan,Apaydin Tugce,Gazioglu Nurperi,Tanriover Necmettin,Oz Buge,Kadioglu Pinar. Pituitary, 21(4), 335-346.
2017 - A novel pathogenic frameshift variant of CD3E gene in two T-B NK SCID patients from Turkey
FIRTINA SİNEM,Ng Yuk Yin,Hatirnaz Ng Ozden,NEPESOV SERDAR,YEŞİLBAŞ OSMAN,KİLERCİK MELTEM,BURTECENE NİHAN,Cinar Suzan,Camcioglu Yildiz,Ozbek Ugur,Sayitoglu Muge. Immunogenetics, 69(10), 653-659.
2017 - Dysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia
FIRTINA SİNEM,HATIRNAZ NG Özden,ERBİLGİN Yücel,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. Turkish Journal of Medical Sciences, 47(1), 357-363.
2017 - Aberrant Hypermethylation of APC Tumor Supressor Gene in Acute Leukemia Patients
HATIRNAZ NG Özden,FIRTINA SİNEM,ERBİLGİN Yücel,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 27(1), 1-7.
2015 - First Steps of the Genetic Monitorization in Primary Immune Deficiencies in the Lead of Prof. Dr. Işil Barlan in Turkey
ng yuk yin,şişko sinem,HATIRNAZ NG Özden,tatonyan suzin,kaya dilek sever,FIRTINA SİNEM,SAYİTOĞLU MÜGE,ÖZBEK UĞUR. turkısh journal of immunology,
2015 - A possible role for WNT5A hypermethylation in Pediatric Acute Lymphoblastic Leukemia
HATIRNAZ NG Özden,FIRTINA SİNEM,Can İsmail,KARAKAŞ ZEYNEP,Ağaoğlu Leyla,Doğru Ömer,Celkan Tiraje,AKÇAY ARZU,YILDIRMAK ZEYNEP YILDIZ,Timur Çetin,ÖZBEK UĞUR,SAYİTOĞLU MÜGE. Turkish Journal of Hematology, 32(2), 127-135.
2014 - Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort
Niyazoglu Mutlu,SAYİTOĞLU MÜGE,FIRTINA SİNEM,hatipoğlu esra,Gazioglu Nurperi,KADIOĞLU PINAR. Pituitary, 17(3), 220-226.
2012 - Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia
FIRTINA SİNEM,ÖZBEK UĞUR,HATIRNAZ NG Özden,ERBİLGİN Yücel,ÇINAR SUZAN,Yildiz Inci,CELKAN TÜLİN TIRAJE,ANAK SENİYE SEMA,Unuvar Aysegul,Devecioglu Omer,Timur Cetin,Aydogan Gonul,AKÇAY ARZU,ATAY DİDEM,Turkkan Emine,KARAMAN SERAP,Orhaner Betul,SARPER NAZAN,DENİZ GÜNNUR. LEUKEMIA RESEARCH, 36(1), 87-92.
Tıbbi Genetiğin Esasları
2014 - Türkçe, Kitap Tercümesi
ISBN: 978-605-4499-82-3
FIRTINA SİNEM